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Refereed Publications

2023

J. Krumbach, D. Bauer, A. Sharifzadeh, A. Saponaro, R. Lautenschläger, K. Lange, O. Rauh, D. DiFrancesco, A. Moroni, G. Thiel, K. Hamacher. Alkali metal cations modulate the geometry of different binding sites in HCN4 selectivity filter for permeation or block, J. Gen. Physiol. 155(10):e202313364, 2023.
Abstract & PDF-Version

P. Kunzmann, T.D. Müller, M. Greil, J.H. Krumbach, J.M. Anter, D. Bauer, F. Islam, K. Hamacher. Biotite: New tools for a versatile Python bioinformatics library , BMC Bioinformatics 24:236, 2023
Abstract & PDF-Version

2022

F. Wirth, T. Kussel, A. Müller, K. Hamacher, F. Prasser. EasySMPC: A Simple but Powerful No-Code Tool for Practical Secure Multiparty Computing, BMC Bioinformatics 23:531, 2022.
Abstract & PDF-Version

T. Kussel, T. Brenner, G. Tremper, J. Schepers, M. Lablans, K. Hamacher. Record Linkage based Patient Intersection Cardinality for Rare Disease Studies using Mainzelliste and Secure Multi-Party Computation, J. Transl. Med. 20:458, 2022.
Abstract & PDF-Version

T. Birka, K. Hamacher, T. Kussel, H. Möllering, T. Schneider. SPIKE: Secure and Private Investigation of the Kidney Exchange problem, BMC Medical Informatics and Decision Making, 22, 253, 2022.
Abstract & PDF-Version

K. Hamacher, T. Kussel, T. Schneider, O. Tkachenko. PEA: Practical Private Epistasis Analysis using MPC, ESORICS 2022 (27th European Symposium on Research in Computer Security), pp. 320-339, 2022.
Abstract & PDF-Version

R. Wettstein, T. Kussel, H. Hund, C. Fegeler, M. Dugas, K. Hamacher. Secure Multi-Party Computation Based Distributed Feasibility Queries - A HiGHmed Use Case, Stud. Health. Technol. Inform. 296:41-49, 2022.
Abstract & PDF-Version

D. Bauer, J. Wissmann, A. Moroni, G. Thiel, K. Hamacher. Weak Cation Selectivity in HCN Channels results from K+-mediated release of Na+ from selectivity filter binding sites, Functions 3(3): zqac019, 2022.
Abstract & PDF-Version

F. Keul, K. Hamacher. Consistent Quantification of Complex Dynamics via a Novel Statistical Complexity Measure, Entropy, 24(4):505, 2022.
Abstract & PDF-Version

P. Kunzmann, J.M. Anter, K. Hamacher. Adding hydrogen atoms to molecular models via fragment superimposition, Algorithms for Molecular Biology, 17, 7, 2022.
Abstract & PDF-Version

K. Hamacher, T. Kussel, T. von Landesberger, T. Baumgartl, M. Hoehn, S. Scheithauer, M. Marschollek, A. Wulff. Fallzahlen, Reidentifikation und der technische Datenschutz. Ein Aspekt der SARS-CoV-2 Pandemie., Datenschutz und Datensicherheit, 46: 143-148, 2022.
Abstract & PDF-Version

S. Stammler, T. Kussel, P. Schoppmann, F. Stampe, G. Tremper, S. Katzenbeisser, K. Hamacher, M. Lablans. Mainzelliste SecureEpiLinker (MainSEL): Privacy-Preserving Record Linkage using Secure Multi-Party Computation, Bioinformatics 38(6): 1657-1668, 2022.
Abstract & PDF-Version

2021

A. Saponaro, D. Bauer, M. Hunter Giese, P. Swuec, A. Porro, F. Gasparri, A.S. Sharifzadeh, A. Chaves-Sanjuan, L. Alberio, G. Parisi, G. Cerutti, O.B. Clarke, K. Hamacher, H.M. Colecraft, F. Mancia, W. A. Hendrickson, S.A. Siegelbaum, D. DiFrancesco, M. Bolognesi, G. Thiel, B. Santoro, A. Moroni. Gating movements and ion permeation in HCN4 pacemaker channels, Mol. Cell 81, 1-15, 2021.
Abstract & PDF-Version

A. Worring, B. Mayer, K. Hamacher. Genetic Algorithm Niching by (Quasi-)Infinite Memory, Genetic and Evolutionary Computation Conference (GECCO2021), pp. 296-304. 2021.
Abstract & PDF-Version
Best Paper Award

M. Schmidt, K. Hamacher. Identification of biophysical interaction patterns in direct coupling analysis, Phys. Rev. E, 103(4)042418, 2021.
Abstract & PDF-Version

M. Schmidt, I. Schroeder, D. Bauer, G. Thiel, K. Hamacher. Inferring functional units in ion channel pores via relative entropy, Eur. Biophys. J., 50, 37-57, 2021.
Abstract & PDF-Version

Ö. Güllülü, S. Hehlgans, B. Mayer, I. Gößner, C. Petraki, M. Hoffmann, M. Dombrowsky, P. Kunzmann, K. Hamacher, K. Strebhardt, E. Fokas, C. Rödel, C. Münch, F. Rödel. A spatial and functional interaction of a heterotetramer Survivin-DNA-PKcs complex in DNA damage response, Cancer Research, 81:2304-17, 2021.
Best-Paper-of-the-Year-Award of the German Gesellschaft für biologische Strahlenforschung (DeGBS)
Abstract & PDF-Version

2020

P. Kunzmann, B. Mayer, K. Hamacher. Substitution matrix based color schemes for sequence alignment visualizations. BMC Bioinformatics, 21, 209 (2020).
Abstract & PDF-Version

K. Hamacher, S. Katzenbeisser, T. Kussel, S. Stammler. Genomische Daten und der Datenschutz, Datenschutz und Datensicherheit - DuD, 44(2), 87-93, 2020.
Abstract & PDF-Version

2019

A. Porro, A. Saponaro, F. Gasparri, D. Bauer, C. Gross, M. Pisoni, G. Abbandonato, K. Hamacher, B. Santoro, G. Thiel, A. Moroni. The HCN domain couples voltage gating and cAMP response in Hyperpolarization-activated Cyclic Nucleotide-gated channels, eLife 2019;8:e49672.
Abstract & PDF-Version

J. Buchmann, M. Geihs, K. Hamacher, S. Katzenbeisser, S. Stammler. Long-Term Integrity Protection of Genomic Data, EURASIP Journal on Information Security, 16, 2019; doi:10.1186/s13635-019-0099-x.
Abstract & PDF-Version

M. Schmidt, K. Hamacher, F. Reinhardt, T. Lotz, F. Groher, B. Suess, S. Jager. SICOR: Subgraph Isomorphism Comparison of RNA Secondary Structures, IEEE/ACM Transactions on Computational Biology and Bioinformatics, 17:2189-2195, 2019.
Abstract & PDF-Version

A. Boussebayle, D. Torka. S. Ollivaud, J. Braun, C. Bofill-Bosch, M. Dombrowsky, F. Groher, K. Hamacher, B. Suess. Next-level riboswitch development - Implementation of Capture-SELEX facilitates identification of a new synthetic riboswitch, Nucleic Acids Research, 47:4883-4895, 2019.
Abstract & PDF-Version

Ann-C. Groher, S. Jager, C. Schneider, F. Groher K. Hamacher, B. Suess. Tuning the Performance of Synthetic Riboswitches using Machine Learning, ACS Synthetic Biology 8(1):34-44, 2019.
Abstract & PDF-Version

2018

M. Schmidt, K. Hamacher. hoDCA: higher order direct-coupling analysis, BMC Bioinformatics, 19:546, 2018.
Abstract & PDF-Version

K. Hamacher. Hybridization of Stochastic Tunneling with (Quasi)-Infinite Time-Horizon Tabu Search, 11th International Workshop on Hybrid Metaheuristics (HM2019), Lecture Notes in Computer Science (LNCS 11299) pp. 124-135, 2018.
Abstract & PDF-Version

P. Kunzmann, K. Hamacher. Biotite: A unifying open source computational biology framework in Python, BMC Bioinformatics, 19:346, 2018.
Abstract & PDF-Version

C. Marini, A. Porro, A. Rastetter, C. Dalle, I. Rivolta, D. Bauer, R Oegema, C Nava, E. Parrini, D. Mei, C. Mercer, R. Dhamija, C. Chambers, C. Coubes, J. Thevenon, P. Kuentz, S. Julia, L. Pasquier, C. Dubourg, W. Carre, A. Rosati, F. Melani, T. Pisano, M. Giardino, A.M. Innes, Y. Alembik, S. Scheidecker, M. Santos, S. Figueiroa, C. Garrido, C. Fusco, D. Frattini, C. Spagnoli, A. Binda, T. Granata, F. Ragona, E. Freri, S. Franceschetti, L. Canafoglia, B. Castellotti, C. Gellera, R. Milanesi, M.M. Mancardi, D.R. Clark, F. Kok, K.L. Helbig, S. Ichikawa, L. Sadler, J. Neupauerova, P. Lasuthova, K. Sterbova, A. Laridon, E. Brilstra, B. Koeleman, J.R. Lemke, F. Zara, P. Striano, A. Barbuti, D. DiFrancesco, E. LeGuern, R. Guerrini, B. Santoro, K. Hamacher, G. Thiel, A. Moroni, J.C. DiFrancesco, C. Depienne. HCN1 mutation spectrum: from neonatal epileptic encephalopathy to benign generalized epilepsy and beyond, Brain 141(11):3160-3178, 2018.
Abstract & PDF-Version
Editor's Choice

C. Gross, A. Saponaro, B. Santoro, A. Moroni, G. Thiel, K. Hamacher. Mechanical transduction of cytoplasmic-to-transmembrane-domain movements in a hyperpolarization-activated cyclic nucleotide-gated cation channel, J. Biol. Chem. 293(33)12908-12918, 2018.
Abstract & PDF-Version

O. Tkachenko, C. Weinert, T. Schneider, K. Hamacher. Large-Scale Privacy-Preserving Statistical Computations for Distributed Genome-Wide Association Studies ACM Asia Conference on Computer and Communications Security (ASIACCS), pp. 221-235, 2018.
Abstract & PDF-Version

M. Dombrowsky, S. Jager, B. Schiller, B. Mayer, S. Stammler, K. Hamacher, StreaMD: Advanced analysis of Molecular Dynamics using R, J. Comp. Chem., 39:1666-1674, 2018.
Abstract & PDF-Version
Cover Page

F. Groher, C. Bofill-Bosch, C. Schneider, J. Braun, S. Jager K. Geißler, K. Hamacher, B. Suess. Riboswitching with ciprofloxacin-development and characterization of a novel RNA regulator, Nucleic Acids Research, 46:2121-2132, 2018.
Abstract & PDF-Version

2017

D. Demmler, K. Hamacher, T. Schneider, S. Stammler. Privacy-Preserving Whole-Genome Variant Queries, 16th International Conference on Cryptology And Network Security (CANS) , Lecture Notes in Computer Science 11261, pp. 71-92, 2017.
Abstract & PDF-Version

M. Schmidt, K. Hamacher. Three body interactions improve contact prediction within direct-coupling-analysis, Phys. Rev. E, 96(5):052405, 2017.
Abstract & PDF-Version
Editor's Suggestion

J. Buchmann, M. Geihs, K. Hamacher, S. Katzenbeisser, S. Stammler. Long-Term Integrity Protection of Genomic Data, 4th Int. Workshop on Genome Privacy and Security (GenoPri'17), 2017.

P. Boba, K. Hamacher, TransferEntropyPT: An R package to assess transfer entropies via permutation tests, 15th Int. Conf. on Comp. Methods in Systems Biology (CMSB2017), Lecture Notes in Bioinformatics (LNBI 10545) 285-290, 2017.
Abstract & PDF-Version
Web-Site with Code and Tutorial

F. Keul, M. Hess, M. Goesele, K. Hamacher. PFASUM: A substitution matrix from Pfam structural alignments, BMC Bioinformatics, 18:293, 2017.
Abstract & PDF-Version

S. Jager, B. Schiller, P. Babel, M. Blumenroth, T. Strufe, K. Hamacher. StreAM-Tg: Algorithms for Analyzing Coarse Grained RNA Dynamics Based on Markov Models of Connectivity-Graphs, Algorithms for Molecular Biology, 12:15 , 2017.
Abstract & PDF-Version

C. Groß, K. Hamacher, K. Schmitz, S. Jager. Cleavage Product Accumulation Decreases the Activity of Cutinase during PET Hydrolysis J. Chem. Inf. Mod. 57(2):243-255, 2017.
Abstract & PDF-Version

2016

S. Weissgraeber, A. Saponaro, G. Thiel, K. Hamacher. A reduced mechanical model for cAMP-modulated gating in HCN channels, Scientific Reports, 7:40168, 2016.
Abstract & PDF-Version

T. Greiner, S. Bolduan, B. Hertel, C. Gross, K. Hamacher, U. Schubert, A. Moroni, G. Thiel. Ion channel activity of Vpu proteins is conserved throughout evolution of HIV-1 and SIV, Viruses 8(12)325, 2016. Abstract & PDF-Version

M. Hess, D. Jente, J. Wiemeyer, K. Hamacher, M. Goesele. Visual Analysis and Comparison of Multiple Sequence Alignments, Eurographics Workshop on Visual Computing for Biology and Medicine, ISBN 978-3-03868-010-9, The Eurographics Association, 2016.
Abstract & PDF-Version

S. Stammler, S. Katzenbeisser, K. Hamacher. Correcting finite sampling issues in Entropy l-diversity, Privacy in Statistical Databases (PSD 2016), Lecture Notes in Computer Science (LNCS 9867), pp. 135-146, 2016.
Abstract & PDF-Version

S. Jager, B. Schiller, T. Strufe, K. Hamacher. StreAM-Tg : Algorithms for Analyzing Coarse Grained RNA Dynamics based on Markov Models of Connectivity-Graphs, Workshop on Algorithms in Bioinformatics (WABI 2016), Lecture Notes in Computer Science (LNCS 9838), pp. 197-209, 2016.
Abstract & PDF-Version

D. Bensinger, T. Neumann, C. Scholz, C. Voss, S. Knorr, U. Kuckelkorn, K. Hamacher, P. Kloetzel, B. Schmidt. Elastase-like activity is dominant to Chymotrypsin-like activity in 20S Proteasome's β5 catalytic subunit, ACS Chemical Biology 11(7):1800-1804, 2016.
Abstract & PDF-Version

M. Hess, F. Keul, M. Goesele, K. Hamacher. Addressing inaccuracies in BLOSUM computation improves homology search performance, BMC Bioinformatics, 17:189, 2016.
Abstract & PDF-Version

K. Hamacher. Using Lisp Macro-Facilities for Transferable Statistical Tests, 9th European Lisp Symposium, ISBN 978-2-9557474-0-7, pp. 31-38, 2016.
PDF-Version

P. Manns, K. Hamacher. Evolving Smoothing Kernels for Global Optimization, 19th European Conference on the Applications of Evolutionary Computation (EvoApplications), Lecture Notes in Computer Science (LNCS 9598), pp. 56-72, 2016.
Abstract & PDF-Version

O. Buss, S. Jager, S.M. Dold, S. Zimmermann K. Hamacher, K. Schmitz, J. Rudat. Statistical evaluation of HTS assays for enzymatic hydrolysis of β-keto esters, PLoS One, 11(1): e0146104, 2016.
Abstract & PDF-Version

K. Hamacher. Online Presences of Traditional Media vs. Blogs - Redundancy and Unique News Coverage, Media Convergence Handbook Vol.1. Journalism, Broadcasting, and Social Media Aspects of Convergence, ISBN 978-3-642-54484-2, A. Lugmayr,C. Dal Zotto (eds.) Springer-Verlag, pp. 117-130, 2016.
Abstract & PDF-Version

2015

F. Hoffgaard, S.M. Kast, A. Moroni, G. Thiel, K. Hamacher. Tectonics of a K+ channel: the importance of the N-terminus for channel gating, Biochimica et Biophysica Acta - Biomembranes, 1848(12):3197-3204, 2015.
Abstract & PDF-Version
PDB-Structure used as a homology model

B. Schiller, S. Jager, K. Hamacher; T. Strufe. StreaM - a Stream-based Algorithm for Counting Motifs in Dynamic Graphs, 2nd International Conference on Algorithms for Computational Biology, Lecture Notes in Bioinformatics (LNBI 9119), 53-67, 2015.
Abstract & PDF-Version

P. Boba, D. Bollmann, D. Schoepe, N. Wester, J. Wiesel, K. Hamacher. Efficient computation and statistical assessment of transfer entropy. Frontiers in Physics 3(2015)10
Abstract & PDF-Version

C. Scholz, S. Knorr, K. Hamacher, B. Schmidt. DOCKTITE - A Highly Versatile Step-by-Step Workflow for Covalent Docking and Virtual Screening in MOE. J. Chem. Inf. Model. 55(2):398-406, 2015.
Abstract & PDF-Version

2014

N.P. Karvelas, A. Peter, S. Katzenbeisser, E. Tews, K. Hamacher. Privacy Preserving Whole Genome Sequence Processing through Proxy-Aided ORAM, Workshop on Privacy in the Electronic Society (WPES 2014), p.1-10, 2014.
Abstract & PDF-Version

O. Lenz, F. Keul, S. Bremm, K. Hamacher, T. von Landesberger. Visual Analysis of Patterns in Multiple Amino Acid Mutation Graphs Visual Analytics Science and Technology (VAST), 2014 IEEE Conference on pp.93-102, 2014.
Abstract & PDF-Version

C. Voss, C. Scholz, S. Knorr, P. Beck, M.L. Stein, A. Zall, U. Kuckelkorn, P.-M. Kloetzel, M. Groll, K. Hamacher, B. Schmidt. α-Keto phenylamides provide a link between the primed and non-primed substrate binding site in the 20S proteasome. ChemMedChem, 9(11):1860-7187, 2014.
Abstract & PDF-Version

P.  Boba, S. Gries, K. Hamacher. R as an Integration Tool in High Performance Computing - Lessons Learned, Workshop on Simulation Technology at Informatik2014, Lecture Notes in Informatics 232:138-148, 2014.
PDF-Version

K. Hamacher. A Taxonomy of Genomic Privacy and Beyond, PETS Genome Privacy Workshop, Online-Proceedings, 2014.

R. Bose, G. Thiel, K. Hamacher. Clustering of Giant Virus-DNA Based on Variations in Local Entropy, Viruses, 6(6), 2259-2267, 2014.
Abstract & PDF-Version

K. Hamacher. Online Performance Measures for Metaheuristic Optimization, 9th International Workshop on Hybrid Metaheuristics (HM2014), Lecture Notes in Computer Science (LNCS 8457), pp. 169-182, 2014.
Abstract & PDF-Version

B. Mayer, K. Hamacher. Stochastic Tunneling Transformation during Selection in Genetic Algorithms, Genetic and Evolutionary Computation Conference (GECCO2014), 801-806, 2014.
Abstract & PDF-Version

M. Hess, S. Bremm, S. Weissgraeber, K. Hamacher, M. Goesele, J. Wiemeyer, T. von Landesberger. Visual Exploration of Parameter Influence on Phylogenetic Trees, IEEE Computer Graphics & Applications, 34(2): 48-56, 2014.
DOI: 10.1109/MCG.2014.2
Abstract & PDF-Version

M. Hess, J. Wiemeyer, K. Hamacher, M. Goesele. Serious Games for Solving Protein Sequence Alignments - Combining Citizen Science and Gaming, Proc. of GameDays 2014, Lecture Notes in Computer Science (LNCS 8395), pp. 175-185, 2014.
Abstract & PDF-Version

M. Waechter, K. Jaeger, D. Thuerck, S. Weissgraeber, S. Widmer, M. Goesele, K. Hamacher. Using Graphics Processing Units to Investigate Molecular Coevolution, Concurrency and Computation: Practice and Experience, 26(6):1278-1296, 2014.
Abstract & PDF-Version

2013

G. Lauss, C. Schröder, P. Dabrock, J. Eder, K. Hamacher, K.A. Kuhn, H. Gottweis. Towards Biobank Privacy Regimes in Responsible Innovation Societies, Biopreservation and Biobanking, 11:319-323, 2013.
Abstract & PDF-Version

K. Hamacher. Grand challenges in computational physics, Frontiers in Computational Physics, 1:4, 2013.
Abstract & PDF-Version

M. Ober, S. Katzenbeisser, K. Hamacher. Structure and Anonymity of the Bitcoin Transaction Graph, Future Internet, 5(2):237-250, 2013.
Abstract & PDF-Version

K. Hamacher, Information Theoretic Dissection of the Holobiont - Host-Virus Interaction as an Example, Nova Acta Leopoldina, NF 114, No. 391, 307-315, 2013.

K. Hamacher. A New Hybrid Metaheuristic - Combining Stochastic Tunneling and Energy Landscape Paving, 8th International Workshop on Hybrid Metaheuristics (HM2013), Lecture Notes in Computer Science (LNCS 7919), pp. 107-117, 2013.
Abstract & PDF-Version

M. Franz, K. Hamacher, S. Jha, S. Katzenbeisser, H. Schröder. Secure Computations on Non-Integer Values with Applications to Privacy-Preserving Sequence Analysis, Information Security Technical Report 17(3):117-128, 2013.
Abstract & PDF-Version

S. Pape, F. Hoffgaard, M. Dür, K. Hamacher, Distance Dependency And Minimum Amino Acid Alphabets for Decoy Scoring Potentials, J. Comp. Chem., 34: 10-20, 2013.
Abstract & PDF-Version

2012

K. Hamacher, R. Bose. Alternate entropy measure for assessing volatility in financial markets. Phys. Rev. E, 86(5):056112, 2012.
Abstract & PDF-Version

K. Hamacher, Resilience to Leaking - Dynamic Systems Modeling of Information Security, PLoS One, 7(12): e49804, 2012.
Online- & PDF-Version

K. Hamacher, Dynamical regimes due to technological change in a microeconomical model of production, Chaos 22: 033149, 2012.
Abstract & PDF-Version

S. Weißgraeber, K. Hamacher, Generalized Correlations in Molecular Evolution: A Critical Assessment, Proceedings of CBSB12 (From Computational Biophysics to Systems Biology), P. Carloni et al. (eds.), (ISBN 978-3-89336-748-1), pp. 231-234
available in the PDF-Version of the Proceedings

K. Hamacher, T. Greiner, J.L. Van Etten, M. Gebhardt, L.P. Villarreal, A. Moroni, G. Thiel, Phycodnavirus Potassium Ion Channel Proteins Question the Virus Molecular Piracy Hypothesis, PLoS One, 7(6): e38826, 2012
Abstract & PDF

M. Waechter, K. Jaeger, S. Weissgraeber, S. Widmer, M. Goesele, K. Hamacher, Information-Theoretic Analysis of Molecular (Co)Evolution using Graphics-Processing Units, 3rd International Emerging Computational Methods for the Life Sciences Workshop (ECMLS 2012) , 49-58, 2012.
Abstract & PDF-Version
Code (licensed under GPLv3)
Reprint (PDF)

T. Wulfmeyer, C. Polzer, G. Hiepler, K. Hamacher, R. Shoeman, D. Dunigan, J.L. Van Etten, M. Lolicato, A. Moroni, G. Thiel, T. Meckel. Structural organization of DNA in Chlorella viruses, PLoS One, 7(2): e30133, 2012
Online-Version

M. Waechter, K. Hamacher, F. Hoffgaard, S. Widmer, M. Goesele, Is Your Permutation Algorithm Unbiased for n≠2**m ? 9th Int. Conf. on Parallel Processing & Appl.Mathematics (PPAM2011), Lecture Notes in Computer Science (LNCS Volume 7203), pp. 297-306, 2012.
Paper at LCNS - SpringerLink (PDF)

2011

S. Weißgraeber, F. Hoffgaard, K. Hamacher, Structure-Based, Biophysical Annotation of Molecular Coevolution of Acetylcholinesterase, Proteins: Structure, Function, and Bioinformatics, 79(11):3144-3154, 2011.
Abstract & PDF

S. Bremm, T. von Landesberger, M. Hess, T. Schreck, P. Weil, K. Hamacher, Interactive Visual Comparison of Multiple Trees, IEEE Conference on Visual Analytics Science and Technology (VAST2011), 31-40, 2011.
Abstract & PDF

E. Gehrmann, C. Glässer, Y. Jin, B. Sendhoff, B. Drossel, K. Hamacher, The robustness of glycolysis in yeast to internal and external noise. Phys. Rev. E 84:021913, 2011.
Abstract & PDF
This paper was discussed in a viewpoint article in Physics(APS) 4, 63 (2011)
(also selected for publication in the Virtual Journal of Biological Physics Research)

K. Hamacher, S. Katzenbeisser. Public Security: simulations need to replace conventional wisdom., Proceedings of the New Security Paradigms Workshop (NSPW11), ISBN 978-1-4503-1078-9, ACM, pp. 115-124, 2011.
Paper (PDF) at Conference Website

K. Hamacher. Free Energy of Contact Formation in Proteins - Efficient Computation in the Elastic Network Approximation. Phys. Rev. E, 84:016703, 2011. (selected for publication in the Virtual Journal of Biological Physics Research)
Abstract & PDF

T. Strunk, K. Hamacher, F. Hoffgaard, H. Engelhardt, M.D. Zillig, K. Faist, W. Wenzel, F. Pfeifer. Structural Model of the Gas Vesicle Protein GvpA and Analysis of GvpA Mutants in vivo, Molecular Microbiology, 81(1):56-68, 2011
Abstract & PDF-Version

M. Gebhardt, F. Hoffgaard, K. Hamacher, S.M. Kast, A. Moroni, G. Thiel. Membrane anchoring and interaction between transmembrane domains is cruical for K+ channel function, J. Biol. Chem., 286(13):11299-11306, 2011
PubMed entry

B. Deiseroth, M. Franz, K. Hamacher, S. Jha, S. Katzenbeisser, H. Schröder. Towards Secure Bioinformatics Services, Financial Cryptography and Data Security (FC2011), Springer Lecture Notes in Computer Sciences (LNCS 7035), pp. 276-283, 2011
PDF in LNCS volume

K. Hamacher. Efficient quantification of the importance of contacts for the dynamical stability of proteins, J. Comp. Chem., 32(5):810-815, 2011
Abstract & PDF-Version

P. Boba, P. Weil, F. Hoffgaard, K. Hamacher. Intra- and Inter-Molecular Co-Evolution: The Case of of HIV1 Protease and Reverse Transcriptase, Proc. of BIOINFORMATICS 2010 (11% acceptance ratio, Best Paper Award), Springer Communications in Computer and Information Science 127:356-366, 2011
PDF-Version of Preproceedings-Paper,    Supplemental Material
PDF-Version

2010

D. Reker, S. Katzenbeisser, K. Hamacher. Computation of Mutual Information From Hidden Markov Models, Computational Biology and Chemistry, 34:328-333, 2010
Abstract & PDF-Version

B. Deiseroth, M. Franz, K. Hamacher, S. Jha, S. Katzenbeisser, H. Schröder. Secure Computation on Non-Integer Values, 2010 IEEE International Workshop on Information Forensics and Security (WIFS-2010), IEEE Press (ISBN 978-1-4244-9078-3) p. 1-6, 2010
PDF via IEEE-Xplore
IACR preprint

S. Bremm, T. Schreck, P. Boba, S. Held, K. Hamacher. Computing and Visually Analyzing Mutual Information in Molecular Co-Evolution, BMC Bioinformatics, 11:330, 2010
    Abstract & PDF-Version

K. Hamacher. Efficient Perturbation Analysis of Elastic Network Models - Application to Acetylcholinesterase of T. californica, J. Comp. Phys., 229:7309-7316, 2010
Abstract & PDF-Version

K. Hamacher. Temperature dependence of fluctuations in HIV1-Protease, Eur. Biophys. J., 39:1051, 2010
Abstract & PDF-Version

F. Hoffgaard, P. Weil, K. Hamacher. BioPhysConnectoR: Connecting Sequence Information and Biophysical Models, BMC Bioinformatics, 11:199, 2010.
Abstract & PDF-Version

S. Pape, F. Hoffgaard, K. Hamacher. Distance-Dependent Classification of Amino Acids by Information Theory, Proteins: Structure, Function, and Bioinformatics, 78(10):2322-2328, 2010.
Abstract & Preprint

K. Hamacher. Protein Domain Phylogenies - Information Theory and Evolutionary Dynamics, Proc. of BIOINFORMATICS 2010 (11% acceptance ratio), p. 114-122, A. Fred, J. Filipe, H. Gamboa (eds.), ISBN 978-989-674-019-1
PDF-Version

2009

P. Weil, F. Hoffgaard, K. Hamacher. Estimating Sufficient Statistics in Co-Evolutionary Analysis by Mutual Information, Computational Biology and Chemistry 33(6):440-444, 2009.
Abstract & PDF-Version

J. Ackermann, P. Baecher, T. Franzel, M. Goesele, K. Hamacher. Massively-Parallel Simulation of Biochemical Systems, Lecture Notes in Informatics, 154, 739-750, 2009, Proceedings of Massively Parallel Computational Biology on GPUs (BioGPU2009)
Entry at CUDA-Zone
Online-Version

2008

K. Hamacher. Relating Sequence Evolution of HIV1-Protease to Its Underlying Molecular Mechanics , Gene, 422:30-36, 2008.
Abstract & PDF-Version
Erratum (PDF) to correct wrong table headings

K. Hamacher. Coarse-grained molecular models for high-throughput and multi-scale functional investigations, Chem.Cent.J., 2:S14, 2008.
Abstract & PDF-Version

K. Hamacher. Coarse-Grained Molecular Models for High-Throughput and Multi-Scale Functional Investigations, Proceedings of CBSB08 (From Computational Biophysics to Systems Biology), U.H.E. Hansmann, et al. (eds.), (ISBN 978-3-9810843-6-8), NIC Series Volume 40, 97-100, 2008.
PDF-Version

2007

K. Hamacher. Adaptive Extremal Optimization by Detrended Fluctuation Analysis, J.Comp.Phys., 227(2):1500-1509, 2007.
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K. Hamacher. Information Theoretical Measures to Analyze Trajectories in Rational Molecular Design, J.Comp.Chem., 28(16):2576-2580, 2007.
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K. Hamacher. Energy landscape paving as a perfect optimization approach under detrended fluctuation analysis, Physica A 378(2):307-314, 2007.
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2006

K. Hamacher. Adaptation in Stochastic Tunneling Global Optimization of Complex Potential Energy Landscapes, Europhys.Lett. 74(6):944, 2006.
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K. Hamacher, A. Hübsch, J.A. McCammon. A Minimal Model for Stabilization of Biomolecules by Hydrocarbon Cross-Linking, J.Chem.Phys. 124:164907, 2006. (selected for publication in the Virtual Journal of Biological Physics Research)
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K. Hamacher, J.A. McCammon. Computing the amino acid specificity of fluctuations in biomolecular systems, J.Chem.Theo.Comp. 2:873, 2006.
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K. Hamacher, J. Trylska, J.A. McCammon. Dependency Map of Proteins in the Small Ribosomal Subunit. PLoS Comput. Biol. 2(2): e10, 2006.
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2005

K. Hamacher. On Stochastic Global Optimization of one-dimensional functions. Physica A 354:547-557, 2005.
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C. Gros, K. Hamacher, W. Wenzel. Breakdown of the Luttinger sum-rule at the Mott-Hubbard transition in the one-dimensional t1-t2 Hubbard model. Europhys. Lett. 69(4):616, 2005.
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2002

K. Hamacher, C. Gros, W. Wenzel. Interaction-induced collapse of a section of the Fermi sea in the zig-zag Hubbard ladder. Phys. Rev. Lett 88:217203, 2002. (selected for publication in the Virtual Journal of Nanoscale Science & Technology)
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K. Hamacher, J. Stolze, W. Wenzel. Disorder Induced Quantum Phase Transition in Random-Exchange Spin-1/2 Chains. Phys. Rev. Lett. 89:127202, 2002. (selected for publication in the Virtual Journal of Nanoscale Science & Technology)
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J. Sirker, A. Klümper, K. Hamacher. Groundstate properties of two-dimensional dimerized Heisenberg models. Phys. Rev. B, 65:134409, 2002.
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2001

K. Hamacher, "Untersuchung quantenmechanischer Korrelationen mit der Dichtematrix-Renormierungsgruppe", PhD-Thesis, Dortmund University, 2001.
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2000

C. Gros, R. Valenti, J.V. Alvarez, K. Hamacher and W. Wenzel. Test of the frustrated spin-cluster model to describe the low-temperature physics of NaV2O5.    Phys. Rev. B (Rapid Comm.), 62(22):R14617-R14620, 2000.
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P. Stampfuß, K. Hamacher, and W. Wenzel. A massively parallel configuration-selecting multi-reference configuration interaction implementation. J. Mol.Struc.(THEOCHEM), 506:99-106, 2000.
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1999

W. Wenzel and K. Hamacher. A Stochastic tunneling approach for global minimization. Phys. Rev. Lett., 82(15):3003-3007, 1999.
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W. Wenzel and K. Hamacher. Scaling Laws for Protein Folding. In D. Reguera, J.M.G. Vilar, and J.M. Rubi, editors, Statistical Mechanics of Biocomplexity, Springer Lecture Notes in Physics, New York, p. 62-71, 1999. Springer.

K. Hamacher and W. Wenzel. The Scaling Behaviour of Stochastic Minimization Algorithms in a Perfect Funnel Landscape. Phys. Rev. E, 59(1):938-941, 1999.
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1998

K. Hamacher. "Optimierung Hochdimensionaler Funktionen im Hinblick auf die Strukturvorhersage von Proteinen" , 1998. Diploma Thesis. Available on request.

K. Hamacher and W. Wenzel. Scaling behaviour of Minimization Algorithms in a Simple Model of Protein Folding. In Proceedings of the HLRZ-Workshop ``Monte Carlo Approach to Biopolymers and Protein Folding'', Singapore, 1998. World Scientific.
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